Application Spotlight. Mylar ®and Melinex® Used In the Manufacture of Oral Thin Films

Mylar® and Melinex® polyester films from DuPont Teijin Films are versatile films that are trusted by companies worldwide and used in a wide range of applications. One such application is the Oral Thin Films market. 

Oral Thin Films, also known as orally dissolving films, are a drug delivery method used by some pharmaceutical companies to manufacture prescription medications, over-the-counter medications, and supplements. Delivering via orally dissolving strips is beneficial to individuals who otherwise have a difficult time swallowing medications and supplements formulated in pills, tablets, or gels.

Oral Thin Film TechnologyTypically the oral thin film formulation is cast to a film substrate where the formulation cures and then is slit and cut into pieces and packaged in dose-friendly packaging. These pieces are often referred to as strips. The strips can be placed on the tongue and then deliver the medication as they dissolve. 

Tekra Carries Materials for the Oral Dissolving Film MarketTekra is a distributor of Mylar® and Melinex® branded polyester films manufactured by DuPont Teijin Films. We carry several polyester films suitable for use in oral dissolving thin film applications. 

  • Mylar® MLB is an uncoated, transparent, polyester film. Mylar® MLB is commercially available in nominal 48 and 300 gauge.
  • Mylar® MLBT and MLBT2 are available with corona treatment on one or both sides. These products are known as Mylar® MLBT and MLBT2 respectively.
  • Mylar® EB11 is a low-gloss polyester film with a matte surface. It is typically used as a carrier film.
  • Melinex® 377 is a translucent, matte film having a medium surface gloss without an adhesion promotion pretreatment

Composition of Mylar® MLB and MLBTCompositionally, Mylar® MLB and Mylar® MLBT films meet FDA compliance for food packaging/food contact applications and comply with 21 C.F.R. § 177.1630 (“Polyethylene phthalate polymers”) and may be used in contact with all food types, excluding alcoholic beverages, to contain foods during oven cooking or oven baking at temperatures above 250°F.

The Importance of FDA Compliance for Oral Film PharmaceuticalsMany pharmaceutical companies value the FDA food contact approval of these film types as well as the films’ tolerance to wide temperatures ranging between -100°F to 300°F.

These Mylar and Melinex film types are also valued because they are chemically inert, won’t leach, and can be used as a barrier to acids, weak bases, greases and oils, detergents, and other active ingredients.

Please consult your Tekra sales representative when considering the use of MYLAR® MLB or MLBT for medical or pharmaceutical applications.  In all cases, however, it remains the responsibility of the end-user to confirm that the product is technically suitable and fit for its intended end-use application.

 

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